Current Red Cross guidelines state, In most cases, theres no deferral time if you receive a vaccine, a protocol which doesnt sit well with Bridle, who remarked, We dont want [a] transfer of these pathogenic spike proteins to fragile patients who might need a blood transfusion. In what organs can you find the vaccine? doi: 10.1371/journal.pone.0135389. Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus. This false claim originated from: viral social media post. The bioanalysis methods appear to be adequate. Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018 in comparison among (a) local or systemic administration product, (b) commercialized or product in clinical phases, (c) biodistribution measurement modalities, (d) clinical phases of development, (e) used animal species and (f) measurement modalities and biodistribution study duration (refer to Supplementary Table1). "Biodistribution" study of mRNA vaccines. Is there a translated version to English of the study somewhere we can access? Rightly, Bridle is extremely troubled about the current drive to vaccinate children against COVID-19, recently stating insufficient evidence exists to claim the benefits outweigh the risk of vaccinating the younger population. Is there a difference between the spike protein in the virus itself and the spike protein in the vaccines in terms of effects on the body described here? Vaccine Researcher Admits Big Mistake, Says Spike Protein Is Dangerous Toxin.. 2011 Oct;17(10):881-90. doi: 10.1089/acm.2010.0481. https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf, *https://www.bmj.com/content/373/bmj.n958/rr-1, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html, History of Discovery of Vitamin D, Use of Vitamin D in Chronic Disease, Origins of Vitamin D Toxicity. Our toxicology study showed a benign safety profile with just the expected inflammation associated with an immune response to the vaccine. We do not have all the animal or clinical data needed to completely evaluate long term safety of the mRNA vaccines. (LogOut/ 2 Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan. This false claim originated from: viral social media post. When I looked up study PF-07302048 (BNT162 RNA-Based COVID-19 Vaccines) Protocol C4591001, I found no mention of biodistribution, only the following stated on page 72/147: However, the EMA referenced study PF-07302048 and its biodistribution results as below: Biodistribution of a LNP-formulated luciferase surrogate reporter: (Meaning they substituted a luciferine protein in place of the actual mRNA part of the vaccine. The vaccine-induced spike protein does not do this. -, Brooks A., Futrega K., Liang X., Hu X., Liu X., Crawford D.H.G. Since the mRNA in the vaccines has been modified to spew out very high amounts of spike protein (far greater than that of the actual virus), the risk of excessive buildup in the cytoplasm is high. Over 48 hours, distribution was mainly observed to liver, adrenal glands, spleen and ovaries. Image . Using Luciferine to follow biodistribution of a product is common practice. Dr. Byram W. Bridle, Ph.D. says the he and several colleagues gained access to a first-of-its-kind "biodistribution" study out of Japan showing that even when injected in muscle tissue in the arm, the mRNA (messenger RNA) injections from Moderna and Pfizer-BioNTech cause the production of spike proteins that more often than not get into the . The mRNA enters your bloodstream and accumulates in a variety of organs, primarily your spleen, bone marrow, liver, adrenal glands and, in women, the ovaries. and transmitted securely. 2015;99(23):99079922. It only looked at where the lipid nanoparticles go. For the first time ever, the Japanese Regulatory Agency recently gave Bridle and several international collaborators access to a study called the Bio-Distribution Study. The groundbreaking research presents scientists with a more reliable understanding of where COVID-19 messenger RNA (mRNA) vaccines travel in the body after being injected. mRNA-1273 . It is necessary to understand their biodistribution. The objective of this guideline is to provide harmonised recommendations for the conduct of nonclinical biodistribution (BD) studies in the development of gene therapy (GT) products. So the Japanese medicines regulator had required Pfizer to do a study where they looked at how the vaccine distributed around the body, in this case of a . Information about the cons of the vaccines is very difficult to find. I highlighted important points for easier reading. Yet he was 100% correct. 2012;2(4):335345. The signal decreased slowly during the first 72 hours and after 6 and 9 days the signals were further weakened to approximately levels of 18 and 7 times the signals obtained from animals injected with buffer control. Canadian vaccine expert Dr. Byram Bridle recently spoke of the terrifying reasons serious side effects, including heart inflammation and vaccine-induced immune thrombotic thrombocytopenia (VITT), may occur in those who have received the COVID-19 vaccine. Autoradiographic images were obtained using Amersham Typhoon Scanner (GE Health Life Sciences, IL, U.S.A.). Find the original research and move on! You are transferring the vaccine itself, as well as the spike protein, which could result in bleeding and/or blood clots in your child. It is a toxin. Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D. Angiotensin II through binding to its type 1 receptors exerts pro-inflammatory, vasoconstrictive, and prothrombotic effects, while angiotensin (17) has opposing effects In addition, angiotensin II increases cytoplasmic and mitochondrial ROS generation leading to oxidative stress. 1 Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki, Japan. Problems with blood clotting (coagulation) which are also common during COVID-19 disease are also reported. What did the initial Pfizer biodistribution studies show? The first section is labeled: SARS-CoV-2 mRNA Vaccine (BNT162, PF-07302048) 2.6.4 Summary of pharmacokinetic study The Comirnaty/Pfizer-BioNTech Fact Sheet for Healthcare Providers Administering Vaccine clearly states that pre-authorization Pfizer-BioNTech vaccine and the Comirnaty vaccine are equivalent. Stop using our children as shields in this battle that is an adult battle.. Keywords: It has been one of the hardest blogs for me to write and why you did not receive a blog last week! SARS-CoV-2 mRNA Vaccine (BNT162, PF-07302048) 2.6.4 PFIZERCONFIDENTIAL Page 3 1. BNT162b2BioNTechBNT162PfizerPF-07302048 Following are pages from the Pfizer Covid vaccine biodistribution study referred to above. . SARS-CoV-2 MRNA Vaccine (BNT162, PF-0 7302048)2.6.4 . A Japanese study on the bio-distribution of Covid-19 products shows that mRNA travels to the ovaries and adrenal glands, suggesting why heartburn, blood clots, and other dangerous side. I thought this would be an easy blog to write, cut and dry. The biodistribution was also studied in rats using radiolabeled LNP and luciferase modRNA (study 185350).. The sections were washed with 50% EtOH (1 min4). The greatest mean concentration was found remaining in the injection site at each time point in both sexes. Additionally, the EMA document states, "Biodistribution: Several literature reports indicate that LNP-formulated RNAs can distribute rather nonspecifically to several organs such as spleen, heart, kidney, lung and brain. Thrombocytopenia is a commonly-reported side effect of COVID-19 vaccines, as are blood clots, strokes and lethal heart attacks all of which are pointing toward spike proteins causing vascular damage. The argument now becomes whether that approval was legal. According to Kendrick, all of them have two things in common:12. Res Rep Health Eff Inst. Total recovery (% of injected dose) of radiolabeled LNP+modRNA outside the injection site was greatest in the liver (up to 21.5%) and was much less in spleen (1.1%), adrenal glands (0.1%) and ovaries (0.1%). The current study investigated SARS-CoV-2 viral load, biodistribution and anti-SARS-CoV-2 antibody formation in patients suffering from severe corona virus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). Thus, there is accumulation of damaged and dysfunctional mitochondria. It also modulates the adhesion of platelets to the endothelium. However, a Japanese document of the Pfizer vaccine data showed biodistribution beyond the local injection site, with distribution highest in the ovaries at 48 hours. Dr Joseph Mercola Story at-a-glance Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer's biodistribution study from the Japanese regulatory agency. The short answer is: absolutely not. People will continue to gather evidence supporting the vaccine, and people will continue to gather evidence against the vaccine. Pfizers data, however, show the mRNA and subsequent spike protein are widely distributed in the body within hours, This is a serious problem, as the spike protein is a toxin shown to cause cardiovascular and neurological damage. 22 23 24 25 Janssen told The BMJ its covid-19 vaccine leverages the same technology as its Ebola vaccine, which received licensure last June. Please read and agree to the disclaimer before watching this video.. SARS-COV-2 Spikes in Ovaries from Pfizer-BioNTech Vaccine?There has been some uncertaint. After spending 20 hours of research, I found there are no animal biodistribution studies of mRNA vaccines done by Pfizer, Moderna, or J and J published on an internet search. Thus it appears that SARS-CoV-2 hijacks mitochondrial machinery for its own benefit, including DMV biogenesis. Learn more 208-391-4000 To conduct BD studies, it is necessary to understand regulatory requirements, implementation status, and analytical methods. And, since the spike protein doesnt enter into the membrane of the cell, theres a high risk that it can become problematic if indeed it works like a prion. When in circulation, the spike protein can bind to the receptors that are on our platelets and the cells that line our blood vessels. A study with the same platform vector ChAdOx -1 (hepatitis B virus) and two studies with a similar viral vector (ChAd63) were also carried out and the results are summarised qualitatively in the EPAR. Women have reported changes in menstruation after taking mRNA vaccines. It also has reproductive toxicity, and Pfizers biodistribution data show it accumulates in womens ovaries, Once in your blood circulation, the spike protein binds to platelet receptors and the cells that line your blood vessels. Read our disclaimer for details. 2. Technically, it is not following the mRNA vaccine itself but following where the LNP container-luciferine goes as a surrogate to understanding where the mRNA may go. Its the first time ever scientists have been privy to seeing where these messenger RNA [mRNA] vaccines go after vaccination, Bridle told Pierson.10. Since spike proteins cause the coronavirus infection, they are the catalyst used in COVID-19 vaccines. However, while the spike protein found in the virus is bad, the spike protein your body produces in response to the vaccine is far worse. A biodistribution study of the Pfizer Covid-19 injection suggests a suspension of the use of mRNA 'Vaccines' is urgently required and blood donor organisations need to take a long hard look at their policies surrounding the acceptance of donations of blood from people who have received an mRNA based Covid-19 injection. Instead it stays open and remains attached to the ACE2 receptor, thereby disabling it and causing a host of problems that lead to heart, lung and immune impairment. The results in this review will be a useful resource for implementing BD studies. Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. Walker VE, Walker DM, Meng Q, McDonald JD, Scott BR, Seilkop SK, Claffey DJ, Upton PB, Powley MW, Swenberg JA, Henderson RF; Health Review Committee. He explained that critical information has recently been discovered that centers around spike proteinsa crucial element in both the SARS-CoV-2 virus and the COVID-19 vaccines. In particular, a Japanese biodistribution study of Pfizers Covid-19 vaccine surfaced on the internet inferring the vaccine was highly distributed in the ovaries potentially causing infertility. The designers of the COVID-19 vaccines expected the contents of a jab to remain in the muscular tissue where they were injected, usually an arm. This assumption was wrong. A study document obtained from the Japanese regulatory agency shows that the vaccine contents enter the bloodstream and travel to the various organs.Lab animals injected with purified spike protein into their bloodstream developed cardiovascular problems, and the spike protein was also demonstrated to cross the blood brain barrier and cause damage to the brain. in Japan for DNA vaccines and recombinant virus vaccines, or prior to the initiation of a large-scale clinical trial in Japan for LNP-mRNA vaccines. Using mRNA programmed to produce luciferase protein, as well as mRNA tagged with a radioactive label, Pfizer showed that the majority of the mRNA initially remain near the injection site, but within hours become widely distributed within the body.9. Dr. Bret Weinstein, Dr. Robert Malone, Steve Kirsch The results from this study supported many of the results from the biodistribution-only studies. Anyway, the answer to this question unfortunately is that they go pretty much everywhere. Apart from its role in energy production, mitochondria are crucial for innate immunity, reactive oxygen species (ROS) generation, and apoptosis; all of these are important in COVID-19 pathogenesis. After the protein piece is made, the cell breaks down the instructions and gets rid of them. 2021 The Japanese Society for Regenerative Medicine. This is a nonprofit education and research site. Nothing whatsoever on this site is monetized, not even the Amazon links. I therefore claim fair use of materials featured here. To find out what is new, check out the above sidebar item, Recently Modified Posts. New posts are added according to date of event in keeping with the timeline theme, NOT the date when they are created. Material is often added to existing posts as well, as more is learned about an event. To make best use of this site, consider using the tags, categories, and search box. Many posts also have a See also, on this site list. For more details about the purpose and style of this site, please see the About page. The FDA has broken at least two federal rules to release these shots under the EUA. He said the study shows how the. At vascular endothelium, ACE2 performs conversion of angiotensin II to angiotensin (17). I live in Japan. Furthermore, in key studies designed to test whether the vaccine remains near the injection site or travels throughout the body, Pfizer did not even use the commercial vaccine (BNT162b2) but instead relied on a surrogate mRNA producing the luciferase protein. https://t.co/bvncGZWV4v pic.twitter.com/aNxH6bkAS5. Specific alterations make it far more toxic than that found on the virus itself. When a substance is injected into the body, tracking where it goes- its biodistribution is important to know. Adams AJ, LaBonte JP, Ball ML, Richards-Hrdlicka KL, Toothman MH, Briggs CJ. In a separate study, mice received IV injection of an imaging dose of [ 52 Mn]MnCl 2, followed by in vivo imaging by positron emission tomography (PET) and ex vivo biodistribution. 2012 Mar;64(3):375-83. doi: 10.1002/acr.21558. Mikovits goes so far as to call the spike protein a bioweapon, as it is a disease-causing agent that demolishes innate immunity and exhausts your natural killer (NK) cells ability to determine which cells are infected and which arent. and when exactly? The spike protein gets into the blood, circulates through the blood in individuals over several days post-vaccination. The EIN for the organization is 59-1630423. When an immune response is launched against the spike protein, the virus stops infecting the body. Ultimately at this juncture, it is a personal decision considering the risk vs. benefit ratio. For the first time ever, the Japanese Regulatory Agency recently gave Bridle and several international collaborators access to a study called "the Bio-Distribution Study." The groundbreaking research presents scientists with a more reliable understanding of where COVID-19 messenger RNA (mRNA) vaccines travel in the body after being injected. See the post about the approval for details. We thought the spike protein was a great target antigen; we never knew it was a toxin. This assumption was wrong. The bottom line is mRNA Covid vaccines are still considered experimental by the FDA as research continues to be done. Remember to check the date when the fact-check you are reading was published before sharing it. They confirmed what I had found. It was a pre-clinical biodistribution study. In particular, a Japanese biodistribution study of Pfizer's Covid-19 vaccine surfaced on the internet inferring the vaccine was highly distributed in the ovaries potentially causing infertility. 8.6. Any objections based on the experimental status of this vaccine are now moot. Many different unusual, prolonged, or delayed reactions have been reported, and often these are more pronounced after the second shot. Stem Cells Transl Med. Content Deleted, Powerful Billionaires Threaten Mercola, The Strange, New Pattern Showing Up After COVID Vaccine, New World Order Yields to the Great Reset, Worse Than The Disease: Reviewing Some Possible Unintended Consequences of mRNA Vaccines Against COVID-19, Princess of Thailand Potential Heiress to the Throne, Grassley: How My Investigation Into Biden Family Financial Dealings Was Sabo taged, Train Derailment Ground Zero Eye Report, New Palestine Train Derailment and Hazardous Materials, Mike Adams Editorial on Destruction of the Nordstream Pipeline, How America Took Out the Nordstream Pipeline, Reporter Seymour Hersh on How America Took Out the Nord Stream Pipeline: Exclusive TV Interview. The https:// ensures that you are connecting to the Prions are membrane proteins and when they misfold, they form crystals in the cytoplasm resulting in prion disease. It only means the studies are not available on an internet search. Trends of cell quantification using Alu-qPCR methods. eCollection 2020 Sep 11. Change), You are commenting using your Twitter account. Dysfunctional mitochondria predispose to oxidative stress and loss of cellular function and vitality. Generally speaking, there are many different kinds and types of vaccines, all with the same objectivetricking a healthy body into thinking it is under attack by a particular disease so the immune system will learn to create the cells and proteins necessary to swiftly destroy the pathogen if it becomes a threat. For Vaxzevria, a single-dose intramuscular biodistribution study with AZD1222 in mice (study 514559) was submitted post-authorisation. Japan has administered COVID-19 vaccine doses to more than 10 million people, the Prime Minister's Office said Wednesday, as the country tries to speed up inoculations that are lagging far behind other developed countries. Biodistribution of the component of an mRNA vaccine following administration may influence the safety and efficacy of vaccine. So, by vaccinating people we are inadvertently inoculating them with a toxin.. What did the initial Pfizer biodistribution studies show? Bipolar disorder and complementary medicine: current evidence, safety issues, and clinical considerations. Documents obtained from Japanese regulatory agency reveal that Pfizer biodistribution studies showed that mRNA and spike proteins circulate widely throughout the body. Explanation: We deem this post as disinformation when it is claimed that the spike protein attacks the ovaries, the neurological system, and other organs. You are not transferring antibodies. Nanoparticles with positively charged surfaces tend to accumulate in the liver, lung, and spleen [ 34 ]. Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. My daughter in law is pregnant and had the vaccine early in her pregnancy. Shockingly, according to Bridle, the COVID-19 vaccine is different from traditional vaccines. Until recently, the opinion has been that these vaccines function like traditional vaccines and remain near the injection site. A recent study from the University of Rochester reveals how the biodistribution kinetics and the affinity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for many different organs . We thought the spike protein was a great target antigen; we never knew the spike protein itself was a toxin and was a pathogenic protein. The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines. 8.7. The Japanese biodistribution study of Pfizer's mRNA vaccine has also found that 0.02% and 0.009% of the vaccine administered dose ended up in the brain at 2-hour and 48-hour, respectively: ), To determine the biodistribution of the LNP-formulated modRNA, the applicant did study, determined the biodistribution of a surrogate luciferase modRNA formulated with a LNP with identical lipid composition used in BNT162b2 (mouse study), or the biodistribution of a [3H]-Labelled. Labeled, "Pfizer confidential," the study is known as a bio-distribution study that uses luciferase enzymes and radioisotope markers to accurately track the distribution of Pfizer's mRNA LNPs across the body. The second source Bridle cited during his interview is a "biodistribution study" obtained from the Japanese Pharmaceuticals and Medical Devices Agency. I am giving you the technical version so you can see for yourself the actual data reviewed by EMA. The site is secure. Its past time to #RevoketheEUA https://t.co/ZdeHCKXyPb, BREAKING: Dr. Byram Bridle sent me his report: 'Why Parents, Teens, and Children Should Question the COVID-19 Vaccine'He's an Associate Professor of Viral Immunology at the University of Guelph who brought attention to the Pfizer Japanese study. When the spike protein interacts with the ACE2 receptor, it can disrupt mitochondrial signaling, thereby inducing the production of reactive oxygen species and oxidative stress. No traditional pharmacokinetic or biodistribution studies have been performed with the vaccine candidate BNT162b2. Assuming that the spike protein would not enter into the circulatory system was a grave mistake, according to Bridle, who calls the Japanese data clear-cut evidence that the vaccine, and the spike protein produced by it, enters your bloodstream and accumulates in vital organs. Brindle, who stated the importance of sharing this new information openly, recently visited On Point with Alex Pierson and spoke at length on the scary situation facing humanity as the push to vaccinate the global population against SARS-CoV-2 gains momentum. No, the Japanese biodistribution study shows nothing of the sort. As a public-health body safeguarding medicines in the European Union (EU), EMA only recommends approval of a vaccine for COVID-19 after a thorough evaluation demonstrating the same high . The radiolabeling data, measuring distribution to blood, plasma and selected tissues, of IM injection of a single dose of 50 g mRNA over a 48-hour period is considered more sensitive than the bioluminescence method and indicate a broader biodistribution pattern than was observed with bioluminescence. 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